Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALOPECIA AREATA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALOPECIA AREATA |
Knowledge base pages for this entity
graph TD
ALOPECIA_AREATA["ALOPECIA AREATA"]
ALOPECIA_AREATA -.biomarker for.-> Cort["Cort"]
ALOPECIA_AREATA -.biomarker for.-> ACTH["ACTH"]
ALOPECIA_AREATA -->|"associated_with_higher_tone"| hypothalamic_pituitary_adrenal["hypothalamic-pituitary-adrenal axis"]
Stress["Stress"] -->|"contributes to"| ALOPECIA_AREATA
Hypothalamic_Pituitary_Adrenal["Hypothalamic-Pituitary-Adrenal Axis"] -->|"contributes to"| ALOPECIA_AREATA
Stress_Response["Stress Response"] -->|"contributes to"| ALOPECIA_AREATA
Corticosterone["Corticosterone"] -.biomarker for.-> ALOPECIA_AREATA
ACTH -.biomarker for.-> ALOPECIA_AREATA
IL12["IL12"] -->|"involved_in"| ALOPECIA_AREATA
TNF["TNF"] -->|"involved_in"| ALOPECIA_AREATA
CYTOKINES["CYTOKINES"] -->|"causes"| ALOPECIA_AREATA| Target | Relation | Type | Str |
|---|---|---|---|
| Hypothalamic-Pituitary-Adrenal Axis | associated_with | pathway | 0.95 |
| Cort | biomarker_for | compound | 0.85 |
| ACTH | biomarker_for | protein | 0.85 |
| hypothalamic-pituitary-adrenal axis | associated_with_higher_tone | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Stress | contributes_to | process | 0.90 |
| Hypothalamic-Pituitary-Adrenal Axis | contributes_to | pathway | 0.90 |
| Hypothalamic-pituitary-adrenal axis | drives | pathway | 0.90 |
| Stress Response | contributes_to | process | 0.88 |
| CRH | associated_with | gene | 0.85 |
| AVP | associated_with | gene | 0.85 |
| POMC | associated_with | gene | 0.85 |
| CRH | upregulates | gene | 0.85 |
| AVP | upregulates | gene | 0.85 |
| TNF | associated_with | gene | 0.80 |
| Corticosterone | biomarker_for | compound | 0.80 |
| ACTH | biomarker_for | compound | 0.80 |
| IL12 | associated_with | gene | 0.80 |
| TNF | involved_in | gene | 0.75 |
| IL12 | involved_in | gene | 0.75 |
| CYTOKINES | causes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||